B.S. Biology, Siena College, Loudonville, NY
Ph.D., Miami University, Oxford, OH
Post-Doctoral Fellow at the University of Cincinnati Medical College
Immunology and Microbiology
K.Siobhan Barone is currently a Professor and Chair in the Department of Biology at Thomas More College. Having completed her Ph.D. degree in Microbiology at Miami University (Oxford, Ohio), she assumed a post-doctoral fellowship position for three years at the University of Cincinnati Medical Center. For the past several years, she has taught the first semester of General Biology for biology majors as well as Immunology, Microbiology and Biochemistry for upper classmen. In addition, she is the premedical advisor and the faculty advisor for the premedical society. Dr. Barone’s primary research interest is in Immunology and she has performed NIH sponsored research in that field with Thomas More College students. This research resulted in presentations at national conferences, such as the American Association of Immunologists (AAI) and the Autumn Immunology Conferences, as well as two peer-reviewed publications. Dr. Barone is currently in the process of writing a third NIH grant in order to continue student-based research projects on the Thomas More College campus.
Courses Taught: General Biology, Immunology, Microbiology, Medical Microbiology, and Biochemistry.
Research Interests: Investigating the mechanisms involved in the induction and maintenance of oral tolerance. Oral tolerance is defined as a temporary loss of systemic immunological responsiveness to a specific soluble antigen after ingestion of that same antigen. The development of this phenomenon may have the evolutionary advantage of preventing hypersensitivity reactions to ingested food proteins. In addition, it may aid in reducing the risk of inducing autoimmune reactions via cross-reactivity of ingested proteins with self-antigens. While oral tolerance has been observed and studied for years, the mechanism responsible for inducing this suppressed immune state remains to be fully elucidated. Interest in discovering the underlying mechanism of oral tolerance has recently intensified, due to the therapeutic potential it holds in the treatment of certain autoimmune diseases such as diabetes, rheumatoid arthritis, multiple sclerosis and uveitis.
Selected Publications: Barone, K. S., R. Burns, S. Horton, A. Retana, L. Jackson, M. Wall and T. Nolan. 2008. “Role of CTLA-4, IL-18 and IL-10 on the Induction of Low Dose Oral Tolerance”. Journal of Kentucky Academy of Science 69: 11-18. Read Article Here Barone, K. S., B. Herms, L. Karlosky, S. Murray and J. Qualls. 2002. “Effect of in vivo administration of anti-CTLA-4 mAb and IL-12 on the induction of low dose oral tolerance”. Clinical and Experimental Immunology. 130:196-203. Barone, K. S., M. R. Reilly, M. P. Flanagan and J. G. Michael. 2000. "Abrogation of Oral Tolerance by Feeding Encapsulated Antigen". Cellular Immunology. 199:65-72. Barone, K. S., D. D. Tolarova, I. Ormsby, T. Doetschman and J. G. Michael. 1998. “Induction of Oral Tolerance in TGFB1 Null Mice”. J. Immunol. 161:154. Barone, K. S., S. Jain and J. G. Michael. 1995. "Effect of In Vivo CD8+ and CD4+ Cell Depletion on the Induction and Maintenance of High Dose Oral Tolerance". Cellular Immunology. 163:19-29.
Selected Professional Meetings Horton, Stepahanie, L, Jackson, M. Wall, and K.S. Barone. 2006. " Effect of In Vivo Administration of Anti-CTLA-4 mAb and anti-IL-10 mAb on the Induction of Low Dose Oral Tolerance". Autumn Immunology Conference, Chicago, Illinois. Retana, Armadno, S. Horton and K. S. Barone. 2005. “Effect of In Vivo Administration of anti-CTLA-4 mAb and/or IL-18 on the Induction of Low Dose Oral Tolerance”. Autumn Immunology Conference, Chicago, Illinois. Burns, Rachael, K. Rappold and K. S. Barone. 2005. “Effect of In Vivo Administration of anti-CTLA-4 mAb and Stimulatory anti-CD40 mAb on the Induction of Low Dose Oral Tolerance”. FASEB (AAI), San Diego, CA. The FASEB Journal Vol. 19, No. 4 Abstract # 561.12, page A949. Nolan, T, J. Qualls and K. S. Barone. 2002. Effect of in vivo Administration of anti-CTLA-4 mab and/or Anti-MCP-1 mAb on Th1 Cell Oral Tolerance. Kentucky Academy of Science Annual Meeting, Northern Kentucky University, Highland Heights, KY. Murray, S., J. Qualls and K. S. Barone. 2002. “Effect of In Vivo Administration of anti-CTLA-4 mAb and IL-12 on Low Dose Oral Tolerance”. FASEB (AAI), New Orleans, LA. Barone, K. S., B. Herms and L. Karlosky. 2001. Effect of anti-CTLA-4 and anti-B7.2 Administration on the Induction of Oral Tolerance. FASEB, Orlando, FL Barone, K. S., B. Herms and L. Karlosky. 2001. Effect of anti-CTLA-4 and anti-B7.2 Administration on the Induction of Oral Tolerance. FASEB, Orlando, FL